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Product Details
PA5-47642
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1 µg/mL | - |
Flow Cytometry (Flow) |
0.25 µg per million cells | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse |
Host/Isotype |
Sheep / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CHO-derived recombinant mouse CRACC/SLAMF7 |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 5% trehalose |
Contains |
No Preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2606929 |
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human CRACC is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD319; Leukocyte cell-surface antigen; Novel Ly9; SLAM family member 7
Gene Aliases: 19A; 19A24; 4930560D03Rik; CRACC; CS1; Slamf7
UniProt ID: (Mouse) Q8BHK6
Entrez Gene ID: (Mouse) 75345
Molecular Function:
immunoglobulin receptor superfamily
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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