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Proteintech
CRBN Polyclonal Antibody
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Product Details
28494-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRBN Fusion Protein Ag29353
Conjugate
Form
Liquid
Concentration
333 µg/mL
Amount
49.95 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AD-006; DKFZp781K0715; MGC27358; novel lethal; Protein cereblon; Protein PiL; protein x 0001; unnamed protein product
Gene Aliases: 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; CRBN; MRT2; MRT2A; piL
UniProt ID: (Human) Q96SW2, (Mouse) Q8C7D2, (Rat) Q56AP7
Entrez Gene ID: (Human) 51185, (Mouse) 58799, (Rat) 297498
protein ubiquitination
positive regulation of Wnt signaling pathway
negative regulation of protein complex assembly
positive regulation of protein complex assembly
negative regulation of ion transmembrane transport
locomotory exploration behavior
proteasome-mediated ubiquitin-dependent protein catabolic process
limb development
proteolysis
negative regulation of protein homooligomerization
positive regulation of protein homodimerization activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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