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Proteintech
CREB3L1/OASIS Polyclonal Antibody
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Product Details
11235-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CREB3L1,OASIS Fusion Protein Ag1757 (170-519 aa encoded by BC015781)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PHQAPGEMT QLPVIKAEPL EVNQFLKVTP EDLVQMPPTP PSSHGSDSDG SQSPRSLPPS SPVRPMARSS TAISTSPLLT APHKLQGTSG PLLLTEEEKR TLIAEGYPIP TKLPLTKAEE KALKRVRRKI KNKISAQESR RKKKEYVECL EKKVETFTSE NNELWKKVET LENANRTLLQ QLQKLQTLVT NKISRPYKMA ATQTGTCLMV AALCFVLVLG SLVPCLPEFS SGSQTVKEDP LAADGVYTAS QMPSRSLLFY DDGAGLWEDG RSTLLPMEPP DGWEINPGGP AEQRPRDHLQ HDHLDSTHET TKYLSEAWPK DGGNGTSPDF SHSKEWFHDR DLGPNTTIKL S (170-519 aa encoded by BC015781)
Target Information
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BBF-2 homolog; cAMP-responsive element-binding protein 3-like protein 1; Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS; old astrocyte specifically induced substance; Old astrocyte specifically-induced substance; Osteogenesis imperfecta, type XVI; unnamed protein product
Gene Aliases: C16DELp11.2; CREB3L1; DEL16p11.2; OASIS; OI16; PSEC0238
UniProt ID: (Human) Q96BA8, (Mouse) Q9Z125, (Rat) Q66HA2
Entrez Gene ID: (Human) 90993, (Mouse) 26427, (Rat) 362165
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
cAMP response element binding
SMAD binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to unfolded protein
negative regulation of gene expression
endoplasmic reticulum unfolded protein response
positive regulation of collagen biosynthetic process
response to endoplasmic reticulum stress
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
extracellular matrix constituent secretion
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of ossification
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
regulation of bone mineralization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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