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Product Details
PA5-23129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mammal,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 75-125 of human CRHR2
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540656
Product Specific Information
Suggested positive control: human brain lysate, human brain protein.
Target Information
Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: corticotrophin releasing hormone receptor 2; corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2; Corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; Corticotropin-releasing hormone receptor 2; corticotropin-releasing hormone receptor type 2 variant 2; CRF 2 receptor; CRF-R 2; CRF-R-2; CRF-R2; CRF-RB; CRF2; CRF2 receptor, beta isoform; CRFR-2; CRH receptor 2 variant B; CRH-R 2; CRH-R-2; CRH-R2; Crh2 receptor; putative corticotropin-releasing hormone receptor type 2
Gene Aliases: CRF-R2; CRF-RB; CRF2; CRF2R; CRFR2; CRFR2alpha; CRFR2beta; CRH-R2; CRH2R; CRHR2; HM-CRF
UniProt ID: (Human) Q13324, (Rat) P47866, (Mouse) Q60748
Entrez Gene ID: (Human) 1395, (Bovine) 521831, (Chicken) 395105, (Dog) 482384, (Rat) 64680, (Mouse) 12922
actin filament organization
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
sensory perception of pain
cerebellum development
hypothalamus development
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
cellular response to corticotropin-releasing hormone stimulus
cellular response to glucocorticoid stimulus
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation
G-protein coupled receptor signaling pathway
feeding behavior
negative regulation of angiogenesis
positive regulation of cAMP metabolic process
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
signal transduction
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