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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid synthetic peptide near the carboxy terminus of human Crim1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/mL|
|Western Blot (WB)||1 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is Jurkat cell lysate.
PA5-34410 can be used with blocking peptide PEP-1452.
CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CRIM-1; CRIM1; cysteine rich transmembrane BMP regulator 1 (chordin-like); Cysteine rich transmembrane BMP regulator 1 chordin-like; Cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52
CRIM-1; CRIM1; S52; UNQ1886/PRO4330