The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK1; CSAID-binding protein; Csaids binding protein; CT-10 related kinase 3; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; mitogen activated protein kinase 14; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38; p38 alpha; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; Proto-oncogene c-Crk; SAPK2a; Stress-activated protein kinase 2a; tRNA synthetase cofactor p38; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein
Gene Aliases: c-Crk; CRK; Crk-I; Crk-II; Crk-III; Crk1; Crk3; CRKII; CrkIII; Crko; CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38-alpha; p38a; p38ALPHA; p38MAPK; PRKM14; PRKM15; RK; SAPK2A