Proteintech

CRLS1 Polyclonal Antibody

CRLS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CRLS1 Antibody (14845-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 14845-1-AP (CRLS1-Specific Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

14845-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

The function of this protein is still unknown. The gene of human hypothetical protein (LOC54675) is up-regulated in colon cancer metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction.

Frontiers in molecular neuroscience

Yang D,Li J,Li Z,Zhao M,Wang D,Sun Z,Wen P,Gou F,Dai Y,Ji Y,Li W,Zhao D,Yang L

Tue Jun 20 00:00:00 UTC 2023

Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria.

International journal of molecular sciences

Montalvo RN,Boeno FP,Dowllah IM,Moritz CEJ,Nguyen BL,Doerr V,Bomkamp MP,Smuder AJ

Sat Apr 22 00:00:00 UTC 2023

Upregulation of LPGAT1 Enhances Lung Adenocarcinoma Proliferation.

Frontiers in bioscience (Landmark edition)

Gong H,Ma C,Li X,Zhang X,Zhang L,Chen P,Wang W,Hu Y,Huang T,Wu N,Wang X

Thu May 11 00:00:00 UTC 2023

Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.

Neural regeneration research

Khan M,Qiao F,Kumar P,Touhidul Islam SM,Singh AK,Won J,Singh I

Sat Jan 01 00:00:00 UTC 2022

Exercise ameliorates high-fat diet-induced insulin resistance accompanied by changes in protein levels of hepatic ATF3-related signaling in rats.

Physiology & behavior

Yang Z,Huang G,Zhou P,Zhang Y,Ding J,Sun Q,Hua T

Sun May 15 00:00:00 UTC 2022

Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.

The Journal of nutritional biochemistry

Wu L,Guo X,Wong SY,Lu P,Hartson SD,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,Chowanadisai W,Lin D

Mon Feb 01 00:00:00 UTC 2021

Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells.

Biochimica et biophysica acta

Peyta L,Jarnouen K,Pinault M,Guimaraes C,Pais de Barros JP,Chevalier S,Dumas JF,Maillot F,Hatch GM,Loyer P,Servais S

Fri Apr 01 00:00:00 UTC 2016

Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells.

Biochimica et biophysica acta

Peyta L,Jarnouen K,Pinault M,Guimaraes C,Pais de Barros JP,Chevalier S,Dumas JF,Maillot F,Hatch GM,Loyer P,Servais S

Fri Apr 01 00:00:00 UTC 2016

Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia.

Biochimica et biophysica acta

Peyta L,Jarnouen K,Pinault M,Coulouarn C,Guimaraes C,Goupille C,de Barros JP,Chevalier S,Dumas JF,Maillot F,Hatch GM,Loyer P,Servais S

Sun Nov 01 00:00:00 UTC 2015

Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia.

Biochimica et biophysica acta

Peyta L,Jarnouen K,Pinault M,Coulouarn C,Guimaraes C,Goupille C,de Barros JP,Chevalier S,Dumas JF,Maillot F,Hatch GM,Loyer P,Servais S

Sun Nov 01 00:00:00 UTC 2015

Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.

The Journal of biological chemistry

Kiebish MA,Yang K,Sims HF,Jenkins CM,Liu X,Mancuso DJ,Zhao Z,Guan S,Abendschein DR,Han X,Gross RW

Fri Jul 20 00:00:00 UTC 2012

Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.

The Journal of biological chemistry

Kiebish MA,Yang K,Sims HF,Jenkins CM,Liu X,Mancuso DJ,Zhao Z,Guan S,Abendschein DR,Han X,Gross RW

Fri Jul 20 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: cardiolipin synthase; Cardiolipin synthase (CMP-forming); cardiolipin synthetase; CLS; Protein GCD10 homolog

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Gene Aliases: 0610009I22Rik; 4930557M15Rik; 5730490M08Rik; C20orf155; CLS; CLS1; CRLS1; dJ967N21.6; GCD10; RGD1311037

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UniProt ID: (Human) Q9UJA2, (Mouse) Q80ZM8, (Rat) Q5U2V5

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Entrez Gene ID: (Human) 54675, (Mouse) 66586, (Rat) 366196

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Function(s)

1-acylglycerol-3-phosphate O-acyltransferase activity cardiolipin synthase activity CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity 2-acylglycerol-3-phosphate O-acyltransferase activity molecular_function transferase activity phosphotransferase activity, for other substituted phosphate groups transferase

Process(es)

cardiolipin biosynthetic process phosphatidylglycerol acyl-chain remodeling lipid metabolic process biological_process phospholipid biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CRLS1 Polyclonal Antibody

CRLS1 Antibody (14845-1-AP) in IHC (P)

Product Details

14845-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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