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CRNN Polyclonal Antibody

CRNN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CRNN Antibody (11799-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human oesophagus tissue slide using 11799-1-AP ( CRNN Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieved with Citric acid buffer, pH6.0.

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Product Details

11799-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CRNN Fusion Protein Ag2374 (196-495 aa encoded by BC030807)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GEGKRNQTT EMRPERQPQT REQDRAHQTG ETVTGSGTQT QAGATQTVEQ DSSHQTGRTS KQTQEATNDQ NRGTETHGQG RSQTSQAVTG GHAQIQAGTH TQTPTQTVEQ DSSHQTGSTS TQTQESTNGQ NRGTEIHGQG RSQTSQAVTG GHTQIQAGSH TETVEQDRSQ TVSHGGAREQ GQTQTQPGSG QRWMQVSNPE AGETVPGGQA QTGASTEPGR QEWSSTHPRR CVTEGQGDRQ PTVVGEEWVD DHSRETVILR LDQGNLHTSV SSAQGQDAAQ SEEKRGITAR ELYSYLRSTK P (196-495 aa encoded by BC030807)

Target Information

This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Altered expression of S100 fused-type proteins in an atopic dermatitis skin model.

Experimental dermatology

Makino T,Mizawa M,Takemoto K,Yamamoto S,Shimizu T

Fri Dec 01 00:00:00 UTC 2023

Protein Profiling in Human Papillomavirus-Associated Cervical Carcinogenesis: Cornulin as a Biomarker for Disease Progression.

Current issues in molecular biology

Kumarasamy G,Ismail MN,Tuan Sharif SE,Desire C,Mittal P,Hoffmann P,Kaur G

Thu Apr 20 00:00:00 UTC 2023

Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia.

Frontiers in cellular and infection microbiology

Gallego C,Jaracz-Ros A,Laganà M,Mercier-Nomé F,Domenichini S,Fumagalli A,Roingeard P,Herfs M,Pidoux G,Bachelerie F,Schlecht-Louf G

Mon Jun 05 00:00:00 UTC 2023

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas.

Molecular & cellular proteomics : MCP

Matas-Nadal C,Bech-Serra JJ,Gatius S,Gomez X,Ribes-Santolaria M,Guasch-Vallés M,Pedraza N,Casanova JM,de la Torre Gómez C,Garí E,Aguayo-Ortiz RS

Thu Jun 01 00:00:00 UTC 2023

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas.

Molecular & cellular proteomics : MCP

Matas-Nadal C,Bech-Serra JJ,Gatius S,Gomez X,Ribes-Santolaria M,Guasch-Vallés M,Pedraza N,Casanova JM,de la Torre Gómez C,Garí E,Aguayo-Ortiz RS

Thu Jun 01 00:00:00 UTC 2023

Expression of Ki-67, Cornulin and ISG15 in non-involved mucosal surgical margins as predictive markers for relapse in oral squamous cell carcinoma (OSCC).

PloS one

Govindaraj PK,Kallarakkal TG,Mohd Zain R,Tilakaratne WM,Lew HL

Tue Jan 11 00:00:00 UTC 2022

Expression of cornulin in tongue squamous cell carcinoma.

Ecancermedicalscience

Saleem S,Aleem I,Atiq A,Tariq S,Babar A,Bakar MA,Syed M,Maruf M,Mahmood MT,Zeshan M,Tahseen M,Hussain R,Loya A,Sutton C

Sat Apr 24 00:00:00 UTC 2021

Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

The Journal of investigative dermatology

Li C,Xiao L,Jia J,Li F,Wang X,Duan Q,Jing H,Yang P,Chen C,Wang Q,Liu J,Shao Y,Wang N,Zheng Y

Tue Jan 01 00:00:00 UTC 2019

Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

The Journal of investigative dermatology

Li C,Xiao L,Jia J,Li F,Wang X,Duan Q,Jing H,Yang P,Chen C,Wang Q,Liu J,Shao Y,Wang N,Zheng Y

Tue Jan 01 00:00:00 UTC 2019

Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

The Journal of investigative dermatology

Li C,Xiao L,Jia J,Li F,Wang X,Duan Q,Jing H,Yang P,Chen C,Wang Q,Liu J,Shao Y,Wang N,Zheng Y

Tue Jan 01 00:00:00 UTC 2019

Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

The Journal of investigative dermatology

Li C,Xiao L,Jia J,Li F,Wang X,Duan Q,Jing H,Yang P,Chen C,Wang Q,Liu J,Shao Y,Wang N,Zheng Y

Tue Jan 01 00:00:00 UTC 2019

Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.

Clinical oral investigations

Salahshourifar I,Vincent-Chong VK,Chang HY,Ser HL,Ramanathan A,Kallarakkal TG,Rahman ZA,Ismail SM,Prepageran N,Mustafa WM,Abraham MT,Tay KK,Zain RB

Tue Dec 01 00:00:00 UTC 2015

Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.

Clinical oral investigations

Salahshourifar I,Vincent-Chong VK,Chang HY,Ser HL,Ramanathan A,Kallarakkal TG,Rahman ZA,Ismail SM,Prepageran N,Mustafa WM,Abraham MT,Tay KK,Zain RB

Tue Dec 01 00:00:00 UTC 2015

Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.

The Journal of thoracic and cardiovascular surgery

Hsu PK,Kao HL,Chen HY,Yen CC,Wu YC,Hsu WH,Chou TY

Thu May 01 00:00:00 UTC 2014

Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.

The Journal of thoracic and cardiovascular surgery

Hsu PK,Kao HL,Chen HY,Yen CC,Wu YC,Hsu WH,Chou TY

Thu May 01 00:00:00 UTC 2014

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.

Journal of proteomics

Katada K,Tomonaga T,Satoh M,Matsushita K,Tonoike Y,Kodera Y,Hanazawa T,Nomura F,Okamoto Y

Fri Mar 16 00:00:00 UTC 2012

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.

Journal of proteomics

Katada K,Tomonaga T,Satoh M,Matsushita K,Tonoike Y,Kodera Y,Hanazawa T,Nomura F,Okamoto Y

Fri Mar 16 00:00:00 UTC 2012

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.

Journal of proteomics

Katada K,Tomonaga T,Satoh M,Matsushita K,Tonoike Y,Kodera Y,Hanazawa T,Nomura F,Okamoto Y

Fri Mar 16 00:00:00 UTC 2012

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.

Journal of proteomics

Katada K,Tomonaga T,Satoh M,Matsushita K,Tonoike Y,Kodera Y,Hanazawa T,Nomura F,Okamoto Y

Fri Mar 16 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Cornulin; Squamous epithelial heat shock protein 53; Tumor-related protein

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Gene Aliases: C1orf10; CRNN; DRC1; Gm1015; PDRC1; SEP53

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UniProt ID: (Human) Q9UBG3

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Entrez Gene ID: (Human) 49860, (Mouse) 381457

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Function(s)

calcium ion binding molecular_function calmodulin-related

Process(es)

response to heat single organismal cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CRNN Polyclonal Antibody

CRNN Antibody (11799-1-AP) in IHC (P)

Product Details

11799-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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