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Bethyl Laboratories
CRSP3 Polyclonal Antibody
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FIGURE: 1 / 1
CRSP3 Antibody (A300-424A) in IP
Detection of human CRSP3 by immunoprecipitation. Samples: Nuclear extract (5 mg) from HeLa cells. Antibody: Affinity purified rabbit anti-CRSP3 antibody (Product # A300-424A) used at 4 µg/5 mg extract. Detection: Coomassie stain. The identity of the band that is CRSP3 was verified by mass spectrometry.
Product Details
A300-424A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 400 and 450 of human Cofactor Required for Sp1 transcriptional activation, subunit 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; Activator-recruited cofactor 130 kDa component; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; DRIP130; hSur-2; Mediator complex subunit 23; Mediator of RNA polymerase II transcription subunit 23; Protein sur-2 homolog; subunit of SRB/mediator complex; Transcriptional coactivator CRSP130; unnamed protein product; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component
Gene Aliases: ARC130; CRSP130; CRSP133; CRSP3; DRIP130; KIAA1216; MED23; MRT18; SUR-2; SUR2
UniProt ID: (Human) Q9ULK4
Entrez Gene ID: (Human) 9439
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of T cell extravasation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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