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Bioss
CRSP77 Polyclonal Antibody
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Product Details
BS-11437R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CRSP77, amino acids 181-280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e. g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD); cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP complex subunit 6; DRIP80; Mediator complex subunit 17; Mediator of RNA polymerase II transcription subunit 17; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; Trap80; Vitamin D3 receptor-interacting protein complex 80 kDa component
Gene Aliases: 77kDa; ARC77; C330002H14Rik; CRSP6; CRSP77; DRIP77; DRIP80; MED17; TRAP80
UniProt ID: (Human) Q9NVC6, (Mouse) Q8VCD5
Entrez Gene ID: (Human) 9440, (Rat) 300367, (Mouse) 234959
RNA polymerase II transcription cofactor activity
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
ligand-dependent nuclear receptor transcription coactivator activity
vitamin D receptor binding
thyroid hormone receptor binding
ubiquitin protein ligase activity
general transcription factor
RNA metabolism protein
nucleic acid metabolism protein
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
protein ubiquitination
stem cell population maintenance
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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