Immunogen sequence: NWNGPHRLYL QMSTHGKVRF RDIASPKFSM PSPVRTVITA DFDNDQELEI FFNNIAYRSS SANRLFRVIR REHGDPLIEE LNPGDALEPE GRGTGGVVTD FDGDGMLDLI LSHGESMAQP LSVFRGNQGF NNNWLRVVPR TRFGAFARGA KVVLYTKKSG AHLRIIDGGS GYLCEMEPVA HFGLGKDEAS SVEVTWPDGK MVSRNVASGE MNSVLEILYP RDEDTLQDPA PLECGQGFSQ QENGHCMDTN ECIQFPFVCP RDKPVCVNTY GSYRCRTNKK CSRGYEPNED GTACVGTLGQ SPGPRPTTPT AAAATAAAAA AAGAATAAPV LVDGDLNLGS VVKESCEPSC; Positive Samples: Mouse brain; Cellular Location: extracellular matrix, extracellular space
CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
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Protein Aliases: 68 kDa chondrocyte-expressed protein; ASPIC; Cartilage acidic protein 1; CEP-68; FLJ10320; Protein CRTAC1-B
Gene Aliases: 2810454P21Rik; Aspic1; AW047536; Cep68; Crtac1; Crtac1B; Lotus
UniProt ID: (Mouse) Q8R555
Entrez Gene ID: (Mouse) 72832