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Invitrogen
CRTH2 Polyclonal Antibody
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Product Details
PA1-4190
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues D(329) D S E L G G A G S S R R R R T S S T A(348) of human G Protein-Coupled Receptor GPR44.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4190 detects GPR44 from human, mouse and rat samples.
PA1-4190 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~66 kDa protein representing GPR44 in GPR44 transfected Jurkat cells.
The PA1-4190 immunogen is a synthetic peptide corresponding to residues D(329) D S E L G G A G S S R R R R T S S T A(348) of human G Protein-Coupled Receptor GPR44.
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that is an identified receptor for the prostaglandin D2 (PGD2) and prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. CRTH2 is also a novel member of the G protein-coupled leukocyte chemoattractant receptor family, which is selectively expressed in Th2 but not Th1 lineage cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated: a 3.5 kb transcript expressed primarily in the thalamus, frontal cortex, pons and hippocampus; and a 3.4 kb transcript expressed in fetal liver, leukocytes and thymus. CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions. At least two different isoforms of CRTH2 are known to exist. Single nucleotide polymorphisms in the 3' UTR of the CRTH2 gene have been associated with asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH2/GPR44; G-protein coupled receptor; DL1R; G protein-coupled receptor 44; G-protein coupled receptor 44; MGC130436; PGD2 receptor; Prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2; putative G-protein coupled receptor 44; unnamed protein product
Gene Aliases: CD294; CRTH2; DL1R; DP2; GPR44; Grp45; PTGDR2
UniProt ID: (Human) Q9Y5Y4, (Mouse) Q9Z2J6, (Rat) Q6XKD3
Entrez Gene ID: (Human) 11251, (Mouse) 14764, (Rat) 309212
chemotaxis
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
calcium-mediated signaling
positive regulation of G-protein coupled receptor protein signaling pathway
cellular response to prostaglandin D stimulus
negative regulation of male germ cell proliferation
chemical synaptic transmission
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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