A suggested positive control is human heart tissue lysate.
PA5-20333 can be used with blocking peptide PEP-0453.
The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
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Protein Aliases: CD294; CD294, Gpr44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH2; DL1R; DP2; G Protein-Coupled Rec. 44; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; PGD receptor; PGD2 receptor; prostaglandin D receptor; Prostaglandin D2 receptor; prostaglandin D2 receptor (DP); Prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2; Prostanoid DP receptor; putative G-protein coupled receptor 44
Gene Aliases: AS1; ASRT1; CD294; CRTH2; DL1R; DP; DP1; DP2; GPR44; Grp45; PGD; PTGDR; PTGDR1; PTGDR2; RGD1565108