Immunogen sequence: GAMRNLYAMH RRLQRHPRSC TRDCAEPRAD GREASPQPLE ELDHLLLLAL MTVLFTMCSL PVIYRAYYGA FKDVKEKNRT SEEAEDLRAL RFLSVISIVD PWIFIIFRSP VFRIFFHKIF IRPLRYRSRC SNSTNMESSL; Positive Samples: NIH/3T3; Cellular Location: Cell membrane, Multi-pass membrane protein
CRTH2 (chemoattractant receptor-homologous molecule), which is also known as the putative G protein-coupled receptor (GPR44), is expressed on Th2 cells and is a novel member of the G protein-coupled leukocyte chemoattractant receptor family, which is selectively expressed in Th2 but not Th1 lineage cells. CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions.
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Protein Aliases: CD294, Gpr44; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G protein-coupled receptor 44; G-protein coupled receptor 44; PGD2 receptor; Prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2
Gene Aliases: Crth2; Gpr44; Grp45; Ptgdr2
UniProt ID: (Mouse) Q9Z2J6
Entrez Gene ID: (Mouse) 14764