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Proteintech
CRX Polyclonal Antibody
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Product Details
12047-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRX Fusion Protein Ag2677 (1-299 aa encoded by BC016664)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Amount
51 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MMAYMNPGP HYSVNALALS GPSVDLMHQA VPYPSAPRKQ RRERTTFTRS QLEELEALFA KTQYPDVYAR EEVALKINLP ESRVQVWFKN RRAKCRQQRQ QQKQQQQPPG GQAKARPAKR KAGTSPRPST DVCPDPLGIS DSYSPPLPGP SGSPTTAVAT VSIWSPASES PLPEAQRAGL VASGPSLTSA PYAMTYAPAS AFCSSPSAYG SPSSYFSGLD PYLSPMVPQL GGPALSPLSG PSVGPSLAQS PTSLSGQSYG AYSPVDSLEF KDPTGTWKFT YNPMDPLDYK DQSAWKFQIL (1-299 aa encoded by BC016664)
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controling the expression of melatonin synthesis genes. Furthermore, CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in the visual pathologies of CORD, Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes although there is no known correlation between the pathologic phenotype and genetic mutation. Missense mutations of the CRX gene affect the homeobox domain, whereas frameshift mutations affect the OTX domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cone rod homeobox; cone-rod homeobox containing; Cone-rod homeobox protein; CORD 2; CRXL1; LCA 7; orthodenticle homeobox 3; OTX; OTX 3; photoreceptor-specific transcription factor
Gene Aliases: CORD2; CRD; CRX; Crx1; LCA7; OTX3
UniProt ID: (Human) O43186, (Mouse) O54751
Entrez Gene ID: (Human) 1406, (Mouse) 12951, (Rat) 60446
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
ligand-dependent nuclear receptor binding
leucine zipper domain binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
nuclear hormone receptor binding
sequence-specific DNA binding
homeodomain transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
visual perception
organ morphogenesis
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
response to stimulus
circadian rhythm
positive regulation of photoreceptor cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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