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Invitrogen

CSB Polyclonal Antibody

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Product Details

PA5-75849

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues in Human CSB.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2719577

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase ERCC6; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; Cockayne syndrome group B protein; Cockayne syndrome protein CSB; CS group B correcting; DNA excision repair protein ERCC-6; excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; unnamed protein product

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Gene Aliases: 4732403I04; ARMD5; C130058G22Rik; CKN2; COFS; COFS1; CSB; CSB-PGBD3; ERCC6; POF11; RAD26; UVSS1

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UniProt ID: (Human) P0DP91, (Mouse) F8VPZ5

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Entrez Gene ID: (Human) 2074, (Rat) 306274, (Mouse) 319955

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Function(s)
nucleotide binding DNA binding DNA helicase activity chromatin binding helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity protein tyrosine kinase activator activity sequence-specific DNA binding RNA polymerase binding chromatin-protein adaptor activity ATP-dependent chromatin remodeler activity ATP-dependent DNA damage sensor activity molecular_function protein C-terminus binding protein complex binding protein N-terminus binding
Process(es)
single strand break repair DNA damage checkpoint response to superoxide positive regulation of defense response to virus by host DNA repair transcription-coupled nucleotide-excision repair base-excision repair pyrimidine dimer repair chromatin remodeling transcription elongation from RNA polymerase I promoter transcription from RNA polymerase II promoter cellular response to DNA damage stimulus response to oxidative stress JNK cascade nervous system development intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to toxic substance response to X-ray response to UV-B response to gamma radiation positive regulation of gene expression protein ubiquitination neurogenesis neuron differentiation neuron projection development regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation positive regulation of peptidyl-serine phosphorylation of STAT protein regulation of transcription elongation from RNA polymerase II promoter multicellular organism growth DNA protection photoreceptor cell maintenance positive regulation of DNA repair positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of transcription initiation from RNA polymerase II promoter protein localization to chromatin double-strand break repair via classical nonhomologous end joining positive regulation of double-strand break repair via homologous recombination negative regulation of double-strand break repair via nonhomologous end joining activation of JNKK activity activation of JUN kinase activity biological_process positive regulation of protein tyrosine kinase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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