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Abnova
CSF2 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
CSF2 Antibody (H00001437-D01P) in WB
Western Blot analysis of CSF2 expression in transfected 293T cell line (H00001437-T01) by CSF2 MaxPab polyclonal antibody.
Lane 1: CSF2 transfected lysate(16.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: CSF2 transfected lysate(16.30 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00001437-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CSF2 (AAI14000.1, 1 a.a. approximately 144 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQIITF ESFKENLKDF LLVIPFDCWE PVQE
Target Information
The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte/macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; molgramostim; Molgramostin; Sargramostim
Gene Aliases: CSF; CSF2; GMCSF
UniProt ID: (Human) P04141
Entrez Gene ID: (Human) 1437
histamine secretion
embryonic placenta development
immune response
signal transduction
JAK-STAT cascade
cell proliferation
positive regulation of cell proliferation
regulation of signal transduction
regulation of gene expression
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
myeloid cell differentiation
neutrophil differentiation
monocyte differentiation
macrophage differentiation
positive regulation of cell migration
positive regulation of interleukin-23 production
response to silicon dioxide
response to fluid shear stress
granulocyte-macrophage colony-stimulating factor signaling pathway
epithelial fluid transport
regulation of cell proliferation
myeloid dendritic cell differentiation
regulation of circadian sleep/wake cycle, sleep
negative regulation of transcription, DNA-templated
regulation of developmental process
positive regulation of leukocyte proliferation
cellular response to lipopolysaccharide
positive regulation of podosome assembly
cellular response to granulocyte macrophage colony-stimulating factor stimulus
dendritic cell differentiation
receptor signaling pathway via STAT
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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