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CSK Polyclonal Antibody

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CSK Polyclonal Antibody

Product Details

BS-12941R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human CSK, amino acids 301-400.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-SRC kinase; c-src tyrosine kinase; CSK; CSK, non-receptor tyrosine kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK; unnamed protein product

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Gene Aliases: AW212630; CSK; p50CSK

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UniProt ID: (Human) P41240, (Rat) P32577, (Mouse) P41241

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Entrez Gene ID: (Human) 1445, (Rat) 315707, (Mouse) 12988

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein phosphatase binding protein kinase A catalytic subunit binding identical protein binding metal ion binding proline-rich region binding protein tyrosine kinase binding receptor binding
Process(es)
morphogenesis of an epithelium protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway brain development negative regulation of cell proliferation negative regulation of low-density lipoprotein particle clearance cell migration negative regulation of interleukin-6 production negative regulation of kinase activity adherens junction organization peptidyl-tyrosine autophosphorylation negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity innate immune response negative regulation of bone resorption protein autophosphorylation oligodendrocyte differentiation negative regulation of phagocytosis regulation of Fc receptor mediated stimulatory signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus adaptive immune response immune system process regulation of immune system process T cell costimulation intracellular signal transduction T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation regulation of multicellular organismal process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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