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Invitrogen
CSK Polyclonal Antibody
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Product Details
PA5-87497
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CSK (NP_0011206621)
Conjugate
Form
Liquid
Concentration
1.14 mg/mL
Amount
114 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT; Positive Samples: HL-60, A-549, Mouse spleen, Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasm
Target Information
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-SRC kinase; c-src tyrosine kinase; CSK; CSK, non-receptor tyrosine kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK; unnamed protein product
Gene Aliases: AW212630; CSK; p50CSK
UniProt ID: (Human) P41240, (Rat) P32577, (Mouse) P41241
Entrez Gene ID: (Human) 1445, (Rat) 315707, (Mouse) 12988
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
protein tyrosine kinase binding
receptor binding
morphogenesis of an epithelium
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
brain development
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
cell migration
negative regulation of interleukin-6 production
negative regulation of kinase activity
adherens junction organization
peptidyl-tyrosine autophosphorylation
negative regulation of Golgi to plasma membrane protein transport
positive regulation of MAP kinase activity
innate immune response
negative regulation of bone resorption
protein autophosphorylation
oligodendrocyte differentiation
negative regulation of phagocytosis
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
adaptive immune response
immune system process
regulation of immune system process
T cell costimulation
intracellular signal transduction
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
regulation of multicellular organismal process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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