MA5-15707 targets CSK in FACS, IF, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15707 immunogen is purified recombinant fragment of human CSK expressed in E. Coli.
MA5-15707 detects CSK which has a predicted molecular weight of approximately 50kDa.
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
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Protein Aliases: C-SRC kinase; CSK; MGC117393; p50CSK; protein-tyrosine kinase (CSK); Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Aliases: AW212630; CSK; p50CSK