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Huabio
CSNK2A2 Polyclonal Antibody
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FIGURE: 1 / 1
CSNK2A2 Antibody (HA500514) in WB
Western blot analysis of CSNK2A2 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA500514, 1:1,000) was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: HeLa cell lysate Lane 2: Mouse testis tissue lysate Lane 3: Rat testis tissue lysate Lane 4: Mouse brain tissue lysate Predicted band size: ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
HA500514
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human CSNK2A2 aa 151-350.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; casein kinase II, alpha 2, polypeptide; CK II alpha'; serine-threonine protein kinase; unnamed protein product
Gene Aliases: 1110035J23Rik; CK2; CK2A2; CK2alpha'; CSNK2A1
UniProt ID: (Human) P19784, (Mouse) O54833
Entrez Gene ID: (Human) 1459, (Mouse) 13000, (Rat) 307641
double-strand break repair
protein phosphorylation
cellular response to DNA damage stimulus
spermatogenesis
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell cycle
regulation of chromosome separation
cerebral cortex development
heterochromatin assembly
regulation of protein catabolic process
positive regulation of transcription, DNA-templated
liver regeneration
regulation of mitophagy
positive regulation of establishment of protein localization to mitochondrion
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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