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Invitrogen
CSPG5 Polyclonal Antibody
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FIGURE: 1 / 1
CSPG5 Antibody (PA5-48089) in WB
Western blot analysis of CSPG5 in SH‚SY5Y human neuroblastoma cell line. Samples were incubated in CSPG5 polyclonal antibody (Product # PA5-48089) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. Specific bands were detected for Neuroglycan C/CSPG5 at approximately 120 and 150 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-48089
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Neuroglycan C/CSPG5 Val31-Gln420
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Neuroglycan C is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Neuroglycan C is a transmembrane chondroitin sulfate proteoglycan that is exclusively expressed in the central nervous system. NGC gene expression is developmentally regulated being altered by addiction to psychostimulants and by nerve lesion. Its core protein has a particular multidomain structure differing from those of other known proteoglycans, and this protein is modified post-translationally in various ways such as phosphorylation and glycosylation. Neuroglycan C is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate chains during the development of the cerebellum and retina. Evidence suggests that Neuroglycan C is involved in neuronal circuit formation in the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acidic leucine-rich EGF-like domain-containing brain protein; chondroitin sulfate proteoglycan; Chondroitin sulfate proteoglycan 5; chondroitin sulfate proteoglycan 5 (neuroglycan C); MGC44034; Neuroglycan C; unnamed protein product
Gene Aliases: CALEB; CSPG5; NGC
UniProt ID: (Human) O95196
Entrez Gene ID: (Human) 10675
cytoskeleton organization
signal transduction
nervous system development
cell differentiation
intracellular transport
cell projection morphogenesis
modulation of synaptic transmission
glial cell projection elongation
positive regulation of substrate adhesion-dependent cell spreading
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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