Proteintech

CTBP2 Polyclonal Antibody

View all (25) CtBP2 antibodies

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CTBP2 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 10346-1-AP (CTBP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

CTBP2 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 10346-1-AP (CTBP2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

CTBP2 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 10346-1-AP (CTBP2 antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours.

CTBP2 Antibody in Immunoprecipitation (IP) — IP result of anti-CTBP2 (IP:10346-1-AP, 4ug; Detection:10346-1-AP 1:500) with mouse heart tissue lysate 3200ug.

Product Details

10346-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
Immunocytochemistry (ICC/IF)	Assay-dependent	View 4 publications 4 publications
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Gerbil, Mouse, Zebrafish
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CTBP2 Fusion Protein Ag0352 (24-201 aa encoded by BC002486) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.33 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: QIMNGPLHP RPLVALLDGR DCTVEMPILK DLATVAFCDA QSTQEIHEKV LNEAVGAMMY HTITLTREDL EKFKALRVIV RIGSGYDNVD IKAAGELGIA VCNIPSAAVE ETADSTICHI LNLYRRNTWL YQALREGTRV QSVEQIREVA SGAARIRGET LGLIGFGRTG QAVAVRAKA (24-201 aa encoded by BC002486)

Target Information

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice.

Neural plasticity

Chang A,Chen P,Guo S,Xu N,Pan W,Zhang H,Li C,Tang J

Tue Dec 11 00:00:00 EST 2018

Hair cell identity establishes labeled lines of directional mechanosensation.

PLoS biology

Lozano-Ortega M,Valera G,Xiao Y,Faucherre A,López-Schier H

Sun Jul 01 00:00:00 EDT 2018

MicroRNA-200 family members are weakly expressed in the neurosensory epithelia of the developing zebrafish (Danio rerio) inner ear.

Genetics and molecular research : GMR

Du JT,Cao H,Zhou W,Chen KT,Jiang D,Tang HC,Wang XR,Zhang XM,Jiang HY

Mon Jun 09 00:00:00 EDT 2014

Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Johnson SL,Forge A,Knipper M,Münkner S,Marcotti W

Wed Jul 23 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: C-terminal-binding protein 2; CtBP2; gene trap ROSA b-geo 6; ribeye; RP11-59C5.2

Gene Aliases: AA407280; CTBP2; D7Ertd45e; Gtrgeo6; Ribeye

UniProt ID: (Human) P56545, (Rat) Q9EQH5, (Mouse) P56546

Entrez Gene ID: (Human) 1488, (Rat) 81717, (Mouse) 13017

Molecular Function: transcription cofactor

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated negative regulation of cell proliferation viral genome replication positive regulation of chromatin binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of retinoic acid receptor signaling pathway white fat cell differentiation oxidation-reduction process regulation of transcription, DNA-templated metabolic process cell differentiation

Process(es)

chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity retinoic acid receptor binding NAD binding oxidoreductase activity