Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.
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Protein Aliases: CCN family member 2; CCN2; Connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); CTGF; fibroblast inducible secreated protein; fibroblast inducible secreted protein; HCS24; hypertrophic chondrocyte-specific gene product 24; Hypertrophic chondrocyte-specific protein 24; IBP 8; IBP-8; IGF binding protein 8; IGF-binding protein 8; IGFBP 8; IGFBP-8; IGFBP8; Insulin-like growth factor-binding protein 8; NOV2; Protein FISP-12
Gene Aliases: CCN2; CTGF; Fisp-12; Fisp12; HCS24; IGFBP8; NOV2