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The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Collagen triple helix repeat-containing protein 1; Protein NMTC1
Gene Aliases: 1110014B07Rik; CTHRC1; UNQ762/PRO1550
UniProt ID: (Human) Q96CG8, (Mouse) Q9D1D6, (Rat) Q8CG08
Entrez Gene ID: (Human) 115908, (Mouse) 68588, (Rat) 282836
Molecular Function:
oxidoreductase
oxygenase
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