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OriGene
CTP synthase Polyclonal Antibody
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Product Details
TA590834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Conjugate
Form
Liquid
Concentration
1.06 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTP synthase 1; CTP synthetase 1; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase; Protein-asparagine deamidase CTPS1; unnamed protein product; UTP--ammonia ligase 1
Gene Aliases: CTPS; CTPS1; GATD5; GATD5A; IMD24
UniProt ID: (Human) P17812
Entrez Gene ID: (Human) 1503
immune system process
nucleobase-containing compound metabolic process
pyrimidine nucleotide biosynthetic process
CTP biosynthetic process
response to xenobiotic stimulus
pyrimidine nucleobase biosynthetic process
T cell proliferation
B cell proliferation
'de novo' CTP biosynthetic process
small molecule metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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