Suggested positive control: human breast cancer and kidney tissue.
The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.
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Protein Aliases: copper transport 1 homolog; Copper transporter 1; Copper uptake transporter 1; CTR1; hCTR1; high affinity copper uptake protein; High affinity copper uptake protein 1; high-affinity copper uptake protein; Liver regeneration-related protein LRRGT00200; rCTR1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1; Solute carrier family 31 member 1
Gene Aliases: 4930445G01Rik; AI787263; AU016967; COPT1; ctr-1; CTR1; LRRGT00200; SLC31A1; Xctr1; XELAEV_18038194mg; zgc:76839