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Invitrogen
CTR1 Polyclonal Antibody
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FIGURE: 1 / 8
CTR1 Antibody (PA1-16586) in ICC/IF
Immunocytochemistry analysis of CTR1 in immersion fixed NIH3T3 Mouse fibroblast cell line. Samples were incubated with CTR1 polyclonal antibody (Product # PA1-16586) using a dilution of 2 µg/mL overnight at 4°C followed by DyLight 488-conjugated Anti-Rabbit IgG (H+L) Cross-Absorbed Secondary Antibody (green). Counterstained with DAPI (blue). Cells were imaged using a 100X objective and digitally deconvolved.
Product Details
PA1-16586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Pig,
Rat,
Xenopus,
Zebrafish
Published species
C. elegans,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from a C-terminal sequence of human SLC31A1/CTR1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: human breast cancer and kidney tissue.
Target Information
The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: copper transport 1 homolog; Copper transporter 1; Copper uptake transporter 1; CTR1; hCTR1; high affinity copper uptake protein; High affinity copper uptake protein 1; high-affinity copper uptake protein; Liver regeneration-related protein LRRGT00200; rCTR1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1; Solute carrier family 31 member 1
Gene Aliases: 4930445G01Rik; AI787263; AU016967; COPT1; ctr-1; CTR1; LRRGT00200; SLC31A1; Xctr1; XELAEV_18038194mg; zgc:76839
UniProt ID: (Human) O15431, (Pig) Q8WNR0, (Rat) Q9JK41, (Mouse) Q8K211
Entrez Gene ID: (Human) 1317, (Pig) 397186, (Dog) 481678, (Rat) 171135, (Mouse) 20529, (Zebrafish) 403028, (Xenopus) 379422
copper ion transport
drug transmembrane transport
cellular copper ion homeostasis
copper ion transmembrane transport
cellular response to cisplatin
copper ion import into cell
copper ion import
transport
ion transport
hypotonic salinity response
response to copper ion
cellular response to estrogen stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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