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Rockland
CTRP1 Polyclonal Antibody
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FIGURE: 1 / 1
CTRP1 Antibody (600-401-AP4) in WB
Western Blot of CTRP1 antibody in MDA-MD-361 cell lysate. Lane A: CTRP1 antibody at 1 µg/mL. Lane B: CTRP1 antibody at 2 µg/mL. Load: 35 µg per lane. Primary antibody: CTRP1 antibody at designated concentrations for overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 32 kDa, 34 kDa for CTRP1. Other band(s): CTRP1 splice variants and isoforms.
Product Details
600-401-AP4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-CTRP1 (IN) antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human CTRP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Complement C1q tumor necrosis factor-related protein 1; G protein coupled receptor interacting protein; G protein-coupled receptor-interacting protein; GIP; Putative secreted protein ZSIG37
Gene Aliases: 1600017K21Rik; C1QTNF1; CTRP1; GIP; UNQ310/PRO353; ZSIG37
UniProt ID: (Human) Q9BXJ1, (Mouse) Q9QXP7
Entrez Gene ID: (Human) 114897, (Mouse) 56745
positive regulation of cytosolic calcium ion concentration
negative regulation of platelet activation
positive regulation of gene expression
regulation of glucose metabolic process
positive regulation of MAPK cascade
protein homooligomerization
positive regulation of protein kinase B signaling
protein heterotrimerization
negative regulation of platelet aggregation
positive regulation of aldosterone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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