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Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CUL4B Fusion Protein Ag15024 (1-195 aa encoded by BC036216) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.33 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Proteintech's CUL4B antibody 20882-1-AP can specifically recognize CUL4B.
Immunogen sequence: MMSQSSGSG DGNDDEATTS KDGGFSSPSP SAAAAAQEVR SATDGNTSTT PPTSAKKRKL NSSSSSSSNS SNEREDFDST SSSSSTPPLQ PRDSASPSTS SFCLGVSVAA SSHVPIQKKL RFEDTLEFVG FDAKMAEESS SSSSSSSPTA ATSQQQQLKN KSILISSVAS VHHANGLAKS STTVSSFANS KPGSAK (1-195 aa encoded by B C036216)
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CUL-4B; cul4b; Cullin-4B
Gene Aliases: 2700050M05Rik; AA409770; CUL-4B; CUL4B; KIAA0695; mKIAA0695; MRXHF2; MRXS15; MRXSC; RGD1564494; SFM2
UniProt ID: (Human) Q13620, (Mouse) A2A432
Entrez Gene ID: (Human) 8450, (Mouse) 72584, (Rat) 302502
Molecular Function:
ubiquitin-protein ligase
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