The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CUL-7; Cullin-7; p185; p193
Gene Aliases: 2510004L20Rik; 3M1; AA409809; C230011P08Rik; CUL7; dJ20C7.5; KIAA0076; p185; p193