Search
Invitrogen
CX3CR1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
CX3CR1 Antibody (720300) in WB
Western blot analysis was performed on Membrane enriched cell extracts (30 µg lysate) of THP-1 (Lane 1), HeLa (Lane 2), SW480 (Lane 3), Hep G2 (Lane 4), Caco-2 (Lane 5) and SH-SY 5Y (Lane 6). The blots were probed with Anti-CX3CR1 Rabbit Polyclonal Antibody (Product # 720300, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 52 kDa band corresponding to CX3CR1 was observed across the cell lines tested. Known q... View More
Product Details
720300
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human CX3CR1 (aa 6-19)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Cat and Mouse
Target Information
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration an d adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; Cx3c; CX3C chemokine receptor 1; Fractalkine receptor; G-protein coupled receptor 13; Scyd1; unnamed protein product; V28
Gene Aliases: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; V28
UniProt ID: (Human) P49238
Entrez Gene ID: (Human) 1524
positive regulation of neuroblast proliferation
adaptive immune response
microglial cell activation involved in immune response
immune system process
response to ischemia
chemotaxis
inflammatory response
immune response
cellular defense response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
brain development
response to wounding
negative regulation of angiogenesis
cytokine-mediated signaling pathway
calcium-mediated signaling
central nervous system maturation
leukocyte chemotaxis
regulation of tumor necrosis factor production
negative regulation of interleukin-1 beta production
social behavior
autocrine signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of nitric oxide biosynthetic process
regulation of synaptic plasticity
host-mediated regulation of intestinal microbiota composition
regulation of neurogenesis
positive regulation of neurogenesis
modulation of synaptic transmission
leukocyte tethering or rolling
positive regulation of protein kinase B signaling
synapse maturation
cell chemotaxis
antifungal innate immune response
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
positive regulation of monocyte chemotaxis
synapse pruning
negative regulation of hippocampal neuron apoptotic process
multiple spine synapse organization, single dendrite
regulation of microglial cell migration
negative regulation of microglial cell mediated cytotoxicity
negative regulation of apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support