This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated. View Details
In direct ELISAs, less than 50% cross-reactivity with recombinant mouse (rm) KC is observed and less than 10% cross-reactivity with recombinant human (rh) GRO alpha, rhGRO beta, rhGRO gamma, rmMIP-2, recombinant rat (rr) CINC-2 alpha, rrCINC-2 beta, and rrCINC-3.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
KC, a homolog of human and hamster gro/MGSA, is a 72 amino acid CXC chemokine originally cloned from rat macrophages and lung tissue. It is the mediator for recruitment and activation of neutrophils in rat lung inflammation models. Expression of KC can be upregulated by LPS and IL-1b stimulation. IFN-gamma blocks LPS induced expression of KC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); CINC-1; CXCL-1; CXCL1; Cytokine-induced neutrophil chemoattractant 1; Fsp; gro; Gro1; Growth-regulated alpha protein; Mgsa; N51; Platelet-derived growth factor-inducible protein KC; Scyb1
Gene Aliases: CINC-1; Cinc1; Cxcl1; Gro; Gro1; Scyb1
UniProt ID: (Rat) P14095
Entrez Gene ID: (Rat) 81503