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Invitrogen

CXCL12 Polyclonal Antibody

2 Published Figures
2 References
View all (26) CXCL12 antibodies

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CXCL12 Polyclonal Antibody

Product Details

PA5-30603

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length human SDF1 Recombinant protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Amount

16 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2548077

Product Specific Information

Recommended positive controls: A549.

Predicted reactivity: Mouse (93%), Rat (92%), Dog (93%), Cat (95%), Pig (90%), Chicken (83%), Rhesus Monkey (97%), Bovine (92%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; CXCL; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; SDF-1 delta; chemokine (C-X-C motif) ligand 12 transcript variant 5; SDF-1 epsilon; chemokine (C-X-C motif) ligand 12 transcript variant 6; SDF-1 gamma; SDF-1 gamma; chemokine (C-X-C motif) ligand 12 transcript variant 4; SDF-1 theta; chemokine (C-X-C motif) ligand 12 transcript variant 7; SDF-1a; SDF-1b; SDF1a; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; stromal cell-derived factor-1 gamma; Thymic lymphoma cell-stimulating factor; TLSF; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1; unnamed protein product

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Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1

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UniProt ID: (Human) P48061, (Mouse) P40224

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Entrez Gene ID: (Human) 6387, (Rat) 24772, (Mouse) 20315

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Function(s)
receptor binding cytokine activity integrin binding protein binding chemokine activity growth factor activity chemokine receptor binding CXCR chemokine receptor binding
Process(es)
patterning of blood vessels response to hypoxia ameboidal-type cell migration neuron migration positive regulation of endothelial cell proliferation immune response germ cell development brain development motor neuron axon guidance positive regulation of cell proliferation adult locomotory behavior germ cell migration response to radiation response to heat response to mechanical stimulus cell migration telencephalon cell migration regulation of cell migration positive regulation of cell migration organ regeneration positive regulation of dopamine secretion T cell proliferation response to peptide hormone positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of axon extension involved in axon guidance induction of positive chemotaxis regulation of calcium ion transport cell chemotaxis chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of myoblast fusion negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of leukocyte tethering or rolling negative regulation of leukocyte apoptotic process positive regulation of T cell migration chemotaxis cellular calcium ion homeostasis defense response cell adhesion signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway axon guidance blood circulation regulation of actin polymerization or depolymerization response to virus T cell chemotaxis killing of cells of other organism integrin activation chemokine (C-X-C motif) ligand 12 signaling pathway CXCL12-activated CXCR4 signaling pathway positive regulation of chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of calcium ion import positive regulation of vasculature development response to ultrasound cellular response to chemokine negative regulation of dendritic cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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