Invitrogen

CXCR3 Polyclonal Antibody

Product Details

71-8800

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

View 5 publications 5 publications

ELISA (ELISA)

Assay-dependent

Product Specifications

Species Reactivity

Mouse

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide derived from the N-terminus of the mouse CXCR3 protein

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2534003

Target Information

CD183, also known as CXCR3, is a seven-transmembrane G protein-coupled chemokine receptor that binds CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC), which are part of the CXC chemokine subfamily. CD183 plays a crucial role in leukocyte traffic, influencing integrin activation, cytoskeletal changes, and chemotactic migration. It is expressed on NK cells, subsets of T lymphocytes, regulatory T cells (Tregs), and is preferentially found on Th1-polarized cells. CD183 is prominently expressed in effector/memory T cells and T cells in inflamed tissues, contributing to CD4 T cell responses to grafts, as evidenced by compromised allograft rejection in CXCR3 knockout mice. Chemokine binding induces rapid, short-lived cellular responses due to receptor internalization, with responsiveness restored after receptor recycling. Inhibition by Bordetella pertussis toxin suggests coupling with Gi subclass G proteins. The production of IP-10, Mig, and I-TAC in inflammatory lesions indicates CD183 role in recruiting inflammatory cells, making it a target for developing antagonists to treat inflammatory diseases. Multiple transcript variants encoding different isoforms of CD183 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model.

Molecular cancer therapeutics

Ma X,Norsworthy K,Kundu N,Rodgers WH,Gimotty PA,Goloubeva O,Lipsky M,Li Y,Holt D,Fulton A

71-8800 was used in immunohistochemistry - paraffin section and western blot to assess the association with poor survival in breast cancer and promotion of metastasis in a murine model due to CXCR3 expression

Sun Mar 01 00:00:00 UTC 2009

Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation.

Immunology and cell biology

Tambuyzer BR,Bergwerf I,De Vocht N,Reekmans K,Daans J,Jorens PG,Goossens H,Ysebaert DK,Chatterjee S,Van Marck E,Berneman ZN,Ponsaerts P

71-8800 was used in flow cytometry to investigate the immunological mechanism leading to rejection of allogeneic bone marrow-derived stromal cells after implantation in murine central nervous system

Fri Jun 19 00:00:00 UTC 2009

Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer.

Cancer research

Sharma S,Yang SC,Zhu L,Reckamp K,Gardner B,Baratelli F,Huang M,Batra RK,Dubinett SM

Wed Jun 15 00:00:00 UTC 2005

CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung.

Infection and immunity

Widney DP,Hu Y,Foreman-Wykert AK,Bui KC,Nguyen TT,Lu B,Gerard C,Miller JF,Smith JB

Sat Jan 01 00:00:00 UTC 2005

CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung.

Infection and immunity

Widney DP,Hu Y,Foreman-Wykert AK,Bui KC,Nguyen TT,Lu B,Gerard C,Miller JF,Smith JB

Sat Jan 01 00:00:00 UTC 2005

Regulation of pulmonary fibrosis by chemokine receptor CXCR3.

The Journal of clinical investigation

Jiang D,Liang J,Hodge J,Lu B,Zhu Z,Yu S,Fan J,Gao Y,Yin Z,Homer R,Gerard C,Noble PW

Thu Jul 01 00:00:00 UTC 2004

EBV-induced molecule 1 ligand chemokine (ELC/CCL19) promotes IFN-gamma-dependent antitumor responses in a lung cancer model.

Journal of immunology (Baltimore, Md. : 1950)

Hillinger S,Yang SC,Zhu L,Huang M,Duckett R,Atianzar K,Batra RK,Strieter RM,Dubinett SM,Sharma S

Mon Dec 15 00:00:00 UTC 2003

Bioinformatics

Protein Aliases: an; C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 3; CC motif chemokine; CCmotif chemokine; CD183; CXC; CXC motif chemokine; CXC-R3; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 receptor

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Gene Aliases: Cd183; Cmkar3; Cxcr3

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UniProt ID: (Mouse) O88410

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Entrez Gene ID: (Mouse) 12766

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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXCR3 Polyclonal Antibody

Product Details

71-8800

Western Blot (WB)

Flow Cytometry (Flow)

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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