CYB5R3 (NADH-cytochrome b5, reductase 3, diaphorase 1) is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis,drug metabolism and, in erythrocytes, methemoglobin reduction.
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Protein Aliases: B5R; Diaphorase (NADH) (cytochrome b-5 reductase); diaphorase 1; diaphorase 1 (NADH); Diaphorase-1; Diaphorase1; mutant NADH-cytochrome b5 reductase; NADH-cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form
Gene Aliases: 0610016L08Rik; 2500002N19Rik; B5R; C85115; CYB5R3; Dia-1; DIA1; Nadhcb5; RNNADHCB5; WU:AL591952.1-001; WU:AL591952.1-002; WU:AL591952.1-003; WU:Cyb5r3