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Invitrogen
CYBA Polyclonal Antibody
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Product Details
PA5-77937
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human p22phox. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: K562, THP-1, HL-60
Predicted Reactivity: Dog (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit; unnamed protein product
Gene Aliases: CGD4; CYBA; p22-PHOX
UniProt ID: (Human) P13498
Entrez Gene ID: (Human) 1535
response to hypoxia
positive regulation of endothelial cell proliferation
negative regulation of glomerular filtration by angiotensin
superoxide metabolic process
inflammatory response
response to xenobiotic stimulus
response to activity
smooth muscle hypertrophy
cytochrome complex assembly
positive regulation of cell growth
response to nutrient levels
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
superoxide anion generation
innate immune response
respiratory burst
positive regulation of blood pressure
positive regulation of smooth muscle cell proliferation
hydrogen peroxide biosynthetic process
positive regulation of phagocytosis
regulation of release of sequestered calcium ion into cytosol
establishment of localization in cell
mucus secretion
positive regulation of mucus secretion
response to interleukin-1
cellular response to mechanical stimulus
cellular response to glucose stimulus
cellular response to tumor necrosis factor
cellular response to gamma radiation
reactive oxygen species metabolic process
positive regulation of defense response to bacterium
positive regulation of reactive oxygen species biosynthetic process
response to aldosterone
cellular response to angiotensin
cellular response to phorbol 13-acetate 12-myristate
cellular response to L-glutamine
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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