Proteintech

CYC1 Polyclonal Antibody

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CYC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 40x lens).

CYC1 Antibody in Western Blot (WB) — Human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

10242-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 15 publications 15 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse
Published species	Artificial Control, Human, Mouse, Pig
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CYC1 Fusion Protein Ag0291 (46-271 aa encoded by BC001006) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.17 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: ALSSKSGLS RGRKVMLSAL GMLAAGGAGL AVALHSAVSA SDLELHPPSY PWSHRGLLSS LDHTSIRRGF QVYKQVCASC HSMDFVAYRH LVGVCYTEDE AKELAAEVEV QDGPNEDGEM FMRPGKLFDY FPKPYPNSEA ARAANNGALP PDLSYIVRAR HGGEDYVFSL LTGYCEPPTG VSLREGLYFN PYFPGQAIAM APPIYTDVLE FDDGTPATMS QIAKDVC (46-271 aa encoded by BC001006)

Target Information

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.

Cancer science

Liu L,Sun Y,Zhao Y,Wang Q,Guo H,Guo R,Liu Y,Fu S,Zhang L,Li Y,Meng Y

Sat Dec 01 00:00:00 EST 2018

Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.

Redox biology

Bharadwaj MS,Zhou Y,Molina AJ,Criswell T,Lu B

Thu Jan 11 00:00:00 EST 2018

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Biochemical and biophysical research communications

Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X

Sat Jun 24 00:00:00 EDT 2017

MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Fan L,Zhu C,Qiu R,Zan P,Zheng Z,Xu T,Li G

Fri Jun 23 00:00:00 EDT 2017

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Nature cell biology

Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

Sat Apr 01 00:00:00 EDT 2017

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Scientific reports

Fu L,Xu Y,Hou Y,Qi X,Zhou L,Liu H,Luan Y,Jing L,Miao Y,Zhao S,Liu H,Li X

Mon Mar 27 00:00:00 EDT 2017

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.

PloS one

Sun S,Han Y,Liu J,Fang Y,Tian Y,Zhou J,Ma D,Wu P

Thu Jan 14 00:00:00 EST 2016

Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates.

Journal of proteome research

Song B,Liu Y,Parman T,Liu S,Miller JK,Liu X,Tanga MJ,Mirsalis J

Fri Dec 05 00:00:00 EST 2014

iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.

Proteomics

Chen H,Xu L,Yin L,Xu Y,Han X,Qi Y,Zhao Y,Liu K,Peng J

Wed Jan 01 00:00:00 EST 2014

Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.

Journal of biochemical and molecular toxicology

Tu JB,Dong Q,Hu XY,Jiang F,Ma RZ,He LY,Yang ZQ

Sat Sep 01 00:00:00 EDT 2012

Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.

Cell research

Zhu Y,Li M,Wang X,Jin H,Liu S,Xu J,Chen Q

Sun Jan 01 00:00:00 EST 2012

Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.

Cell research

Zhu Y,Li M,Wang X,Jin H,Liu S,Xu J,Chen Q

Sun Jan 01 00:00:00 EST 2012

An integrative multi-platform analysis for discovering biomarkers of osteosarcoma.

BMC cancer

Li G,Zhang W,Zeng H,Chen L,Wang W,Liu J,Zhang Z,Cai Z

Sat May 16 00:00:00 EDT 2009

A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice.

Biology of reproduction

Lu B,Poirier C,Gaspar T,Gratzke C,Harrison W,Busija D,Matzuk MM,Andersson KE,Overbeek PA,Bishop CE

Tue Apr 01 00:00:00 EDT 2008

Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes.

Apoptosis : an international journal on programmed cell death

Xiang R,Liu Y,Zhu L,Dong W,Qi Y

Wed Nov 01 00:00:00 EST 2006

Bioinformatics

Protein Aliases: Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Cytochrome c-1; Cytochrome c1, heme protein, mitochondrial; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit

Gene Aliases: 2610002H19Rik; AA408921; CYC1; MC3DN6; UQCR4

UniProt ID: (Human) P08574, (Mouse) Q9D0M3

Entrez Gene ID: (Human) 1537, (Mouse) 66445

Function(s)

mitochondrial electron transport, ubiquinol to cytochrome c response to glucagon transport oxidation-reduction process

Process(es)

heme binding electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity metal ion binding protein binding electron carrier activity