Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
16011-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CYFIP1/2 Fusion Protein Ag8749 (879-1278 aa encoded by BC011762)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This antibody can recognize both CYFIP1 and CYFIP2.
Immunogen sequence: CYNGSTNRF VRTAIPFTQE PQRDKPANVQ PYYLYGSKPL NIAYSHIYSS YRNFVGPPHF KTICRLLGYQ GIAVVMEELL KIVKSLLQGT ILQYVKTLIE VMPKICRLPR HEYGSPGILE FFHHQLKDII EYAELKTDVF QSLREVGNAI LFCLLIEQAL SQEEVCDLLH AAPFQNILPR VYIKEGERLE VRMKRLEAKY APLHLVPLIE RLGTPQQIAI AREGDLLTKE RLCCGLSMFE VILTRIRSYL QDPIWRGPPP TNGVMHVDEC VEFHRLWSAM QFVYCIPVGT NEFTAEQCFG DGLNWAGCSI IVLLGQQRRF DLFDFCYHLL KVQRQDGKDE IIKNVPLKKM ADRIRKYQIL NNEVFAILNK YMKSVETDSS TVEHVRCFQP PIHQSLATTC (879-1278 aa encoded by BC011762)
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CYFIP1; CYFIP2; Cytoplasmic FMR1-interacting protein 1; Cytoplasmic FMR1-interacting protein 2; cytoplasmic FMRP interacting protein 1; p140sra-1; p53-inducible protein 121; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1
Gene Aliases: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP1; CYFIP2; E030028J09Rik; KIAA0068; KIAA1168; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; mKIAA1168; P140SRA-1; P140sra1; PIR121; pl-1; SHYC; SRA-1; SRA1
UniProt ID: (Human) Q7L576, (Human) Q53EN5, (Mouse) Q7TMB8, (Mouse) Q5SQX6
Entrez Gene ID: (Human) 23191, (Human) 26999, (Mouse) 20430, (Mouse) 76884
Molecular Function:
scaffold/adaptor protein
regulation of cell shape
Rac protein signal transduction
lamellipodium assembly
ruffle organization
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
axon extension
cognition
positive regulation of Arp2/3 complex-mediated actin nucleation
apoptotic process
single organismal cell-cell adhesion
positive regulation of proteolysis
activation of cysteine-type endopeptidase activity
multicellular organism development
nervous system development
cell differentiation
cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support