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Invitrogen
CYFIP1 Polyclonal Antibody
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Product Details
PA5-115078
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYFIP1(Accession Q7L576), corresponding to amino acid residues I500-R550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CYFIP1.
Target Information
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; FLJ45151; KIAA0068; p140sra-1; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1; unnamed protein product
Gene Aliases: CYFIP1; KIAA0068; P140SRA-1; SHYC; SRA-1; SRA1
UniProt ID: (Human) Q7L576
Entrez Gene ID: (Human) 23191
cell morphogenesis
regulation of translation
nervous system development
axon guidance
regulation of cell shape
positive regulation of lamellipodium assembly
Rac protein signal transduction
negative regulation of translation
lamellipodium assembly
cell differentiation
regulation of actin filament polymerization
neuron projection development
ruffle organization
axon extension
cognition
positive regulation of neurotrophin TRK receptor signaling pathway
dendrite extension
regulation of translation at postsynapse, modulating synaptic transmission
regulation of modification of postsynaptic actin cytoskeleton
positive regulation of Arp2/3 complex-mediated actin nucleation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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