Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
The antibody detects endogenous levels of total CYFIP2 / PIR121 protein.
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CYFIP2; Cytoplasmic FMR1-interacting protein 2; p53-inducible protein 121
Gene Aliases: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP2; KIAA1168; mKIAA1168; PIR121
UniProt ID: (Human) Q96F07, (Mouse) Q5SQX6
Entrez Gene ID: (Human) 26999, (Mouse) 76884
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