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Invitrogen
CYFIP2 Polyclonal Antibody
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Product Details
PA5-68449
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human CYFIP2 [aa 1171-1220].
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyfip2; cytoplasmic FMR1 interacting protein 2; Cytoplasmic FMR1-interacting protein 2; inducible protein; p53-inducible protein 121; PIR121; unnamed protein product
Gene Aliases: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP2; DEE65; EIEE65; KIAA1168; mKIAA1168; PIR121
UniProt ID: (Human) Q96F07, (Mouse) Q5SQX6
Entrez Gene ID: (Human) 26999, (Mouse) 76884, (Rat) 303073
cell morphogenesis
apoptotic process
cell adhesion
axon guidance
cell projection assembly
regulation of actin filament polymerization
neuron projection development
positive regulation of proteolysis
positive regulation of neurotrophin TRK receptor signaling pathway
dendrite extension
cell-cell adhesion
regulation of postsynapse assembly
single organismal cell-cell adhesion
activation of cysteine-type endopeptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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