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Proteintech

CYLD Polyclonal Antibody

27 References
View all (19) CYLD antibodies

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CYLD Polyclonal Antibody

Product Details

11110-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 20 publications 20 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYLD Fusion Protein Ag1598 (657-956 aa encoded by BC012342)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Amount

33 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human CYLD.

Immunogen sequence: KIMKLRKIL EKVEAASGFT SEEKDPEEFL NILFHHILRV EPLLKIRSAG QKVQDCYFYQ IFMEKNEKVG VPTIQQLLEW SFINSNLKFA EAPSCLIIQM PRFGKDFKLF KKIFPSLELN ITDLLEDTPR QCRICGGLAM YECRECYDDP DISAGKIKQF CKTCNTQVHL HPKRLNHKYN PVSLPKDLPD WDWRHGCIPC QNMELFAVLC IETSHYVAFV KYGKDDSAWL FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR RLLCDAYMCM YQSPTMSLYK (657-956 aa encoded by BC012342)

Target Information

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cyld; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; unnamed protein product

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Gene Aliases: 2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; CYLD; CYLD1; CYLDI; EAC; FTDALS8; HSPC057; KIAA0849; LRRGT00003; MFT; MFT1; mKIAA0849; Rp1; Rp1h; SBS; TEM; USPL2

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UniProt ID: (Human) Q9NQC7, (Rat) Q66H62, (Mouse) Q80TQ2

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Entrez Gene ID: (Human) 1540, (Rat) 312937, (Mouse) 74256

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Function(s)
thiol-dependent ubiquitin-specific protease activity protein binding peptidase activity cysteine-type peptidase activity zinc ion binding hydrolase activity protein kinase binding metal ion binding Lys63-specific deubiquitinase activity ubiquitinyl hydrolase activity, acting on linear ubiquitin proline-rich region binding Lys48-specific deubiquitinase activity molecular_function structural constituent of ribosome thiol-dependent ubiquitinyl hydrolase activity ribosomal protein
Process(es)
immune system process proteolysis I-kappaB kinase/NF-kappaB signaling regulation of mitotic cell cycle regulation of tumor necrosis factor-mediated signaling pathway Wnt signaling pathway protein deubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling CD4-positive or CD8-positive, alpha-beta T cell lineage commitment innate immune response regulation of B cell differentiation positive regulation of T cell differentiation negative regulation of JNK cascade homeostasis of number of cells regulation of inflammatory response negative regulation of inflammatory response positive regulation of T cell receptor signaling pathway regulation of necroptotic process necroptotic process regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination negative regulation of canonical Wnt signaling pathway ripoptosome assembly involved in necroptotic process negative regulation of NIK/NF-kappaB signaling regulation of cilium assembly negative regulation of p38MAPK cascade positive regulation of cellular protein localization protein linear deubiquitination negative regulation of interleukin-18-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway cytoplasmic translation ubiquitin-dependent protein catabolic process biological_process negative regulation of NF-kappaB import into nucleus negative regulation of T cell differentiation
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