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Invitrogen
CYP1A1 Polyclonal Antibody
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FIGURE: 1 / 3
CYP1A1 Antibody (PA5-15212) in IHC (P)
Immunohistochemistry analysis of CYP1A1 in formalin-fixed and paraffin-embedded human lung carcinoma tissue. Samples were incubated with CYP1A1 polyclonal antibody (Product # PA5-15212) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-15212
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 377-405 amino acids from the C-terminal region of human CYP1A1
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
400 µg
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aromatic compound inducible; aryl hydrocarbon hydroxylase; CYP; CYP1A1v; alternatively spliced; CYPIA1; cytochrome P-450 protein; cytochrome P-450-1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; cytochrome P450 family 1 subfamily a polypeptide 2; Cytochrome P450 form 6; cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; functional drug metabolizing enzyme; Hydroperoxy icosatetraenoate dehydratase; P450; P450 form 6; P450-P1; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: AHH; AHRR; CP11; CYP1; Cyp1a-1; CYP1A1; Cyp1a2; CYPIA1; P1-450; P450-1; P450-C; P450DX
UniProt ID: (Human) P04798, (Mouse) P00184
Entrez Gene ID: (Human) 1543, (Mouse) 13076
catalytic activity
monooxygenase activity
iron ion binding
protein binding
arachidonic acid monooxygenase activity
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on diphenols and related substances as donors
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
flavonoid 3'-monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
lyase activity
oxygen binding
enzyme binding
heme binding
Hsp70 protein binding
demethylase activity
metal ion binding
Hsp90 protein binding
vitamin D 24-hydroxylase activity
estrogen 16-alpha-hydroxylase activity
estrogen 2-hydroxylase activity
long-chain fatty acid omega-hydroxylase activity
hydroperoxy icosatetraenoate dehydratase activity
long-chain fatty acid omega-1 hydroxylase activity
aromatase activity
response to hypoxia
long-chain fatty acid metabolic process
liver development
lipid hydroxylation
lipid metabolic process
fatty acid metabolic process
steroid biosynthetic process
steroid catabolic process
porphyrin-containing compound metabolic process
xenobiotic metabolic process
steroid metabolic process
estrogen metabolic process
amine metabolic process
toxin metabolic process
response to xenobiotic stimulus
response to nematode
response to herbicide
response to toxic substance
ethylene metabolic process
coumarin metabolic process
flavonoid metabolic process
response to iron(III) ion
insecticide metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
dibenzo-p-dioxin catabolic process
epoxygenase P450 pathway
response to food
response to lipopolysaccharide
response to vitamin A
response to genistein
response to immobilization stress
xenobiotic catabolic process
vitamin D metabolic process
hormone metabolic process
retinol metabolic process
long-chain fatty acid biosynthetic process
9-cis-retinoic acid biosynthetic process
camera-type eye development
nitric oxide metabolic process
response to arsenic-containing substance
digestive tract development
tissue remodeling
hydrogen peroxide biosynthetic process
response to hyperoxia
maternal process involved in parturition
hepatocyte differentiation
cellular response to copper ion
omega-hydroxylase P450 pathway
olefinic compound metabolic process
positive regulation of G1/S transition of mitotic cell cycle
response to diphenyl ether
response to Aroclor 1254
response to 2,3,7,8-tetrachlorodibenzodioxine
response to 3-methylcholanthrene
drug metabolic process
heterocycle metabolic process
oxidation-reduction process
demethylation
cellular response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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