Immunogen sequence: KEGYGLLILEG EDWQRVRSAF QKKLMKPGEV MKLDNKINEV LADFMGRIDE LCDERGHVED LYSELN
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 79%.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: 1; 1,25-@dihydroxyvitamin D3 24-hydroxylase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; 25-@dihydroxyvitamin D3 24-hydroxylase; CP24; CYP24; CYP24A1; cytochrome P450; Cytochrome P450 24A1; cytochrome P450 family 24 subfamily A polypeptide 1; cytochrome P450, family 24, subfamily A, polypeptide 1; cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; exo-mitochondrial protein; family 24; MGC126273; MGC126274; P450-CC24; polypeptide 1; subfamily A; subfamily XXIV (vitamin D 24-hydroxylase); vitamin D 24-hydroxylase; vitamin D(3) 24-hydroxylase
Gene Aliases: CP24; CYP24; CYP24A1; HCAI; HCINF1; P450-CC24
UniProt ID: (Human) Q5I2W7
Entrez Gene ID: (Human) 1591