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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Purified human CYP2A6 expressed in E.Coli|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Functional Assay (FN)||Assay-dependent|
|Inhibition Assays (IA)||Assay-dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-33085 detects CYP2A6 from human samples.
PA1-33085 has been successfully used in Western blot applications.
The PA1-33085 immunogen is: Purified human CYP2A6 expressed in E.Coli
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; CPA6; CYP2A; CYP2A3; cytochrome P450 IIA3; cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450C2A; P450PB; xenobiotic monooxygenase
CPA6; CYP2A; CYP2A3; CYP2A6; CYPIIA6; P450C2A; P450PB