PA1-342 detects cytochrome P450 (P450) 2A6 from human, mouse and rat samples. This antibody detects, to a lesser extent, other P450 isoforms.
PA1-342 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~49 kDa protein representing P450 2A6 from rat liver extract.
The PA1-342 immunogen is purified, His-tagged, full length human P450 2A6 fusion protein.
The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CYP; CYP2A3; CYPIIA6; Cytochrome P450 2A6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450; P450 IIA3; P450(I); xenobiotic monooxygenase
Gene Aliases: CPA6; CYP2A; CYP2A3; CYP2A6; CYPIIA6; P450C2A; P450PB
UniProt ID: (Human) P11509
Entrez Gene ID: (Human) 1548