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Invitrogen
CYP2C19 Polyclonal Antibody
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FIGURE: 1 / 5
CYP2C19 Antibody (PA5-112395) in ICC/IF
Immunocytochemichal analysis of CYP2C19 in Hela cells using a Polyclonal antibody (Product # PA5-112395) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
Product Details
PA5-112395
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Cytochrome P450 2C19 protein (245-353AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; cyto; cytochrome P-450 II C; Cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; Mephenytoin 4-hydroxylase; microsomal monooxygenase; P450-11A; P450-254C; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; P450C2C; P450IIC19
UniProt ID: (Human) P33261
Entrez Gene ID: (Human) 1557
monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
oxygen binding
enzyme binding
heme binding
metal ion binding
(R)-limonene 6-monooxygenase activity
long-chain fatty acid omega-1 hydroxylase activity
long-chain fatty acid metabolic process
lipid metabolic process
fatty acid metabolic process
terpenoid metabolic process
xenobiotic metabolic process
steroid metabolic process
monoterpenoid metabolic process
epoxygenase P450 pathway
monocarboxylic acid metabolic process
xenobiotic catabolic process
omega-hydroxylase P450 pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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