The synthetic peptide sequence is 194-214aa, FACRFEYNDPRFIRLLDLLKD
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Cytochrome p450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CYPIID18; CYPIID4; Cytochrome P450 2D-29; Cytochrome P450 2D-35; Cytochrome P450 2D18; Cytochrome P450 2D4; cytochrome P450, family 2, subfamily d, polypeptide 22; cytochrome P450, family 2, subfamily d, polypeptide 4; cytochrome P450, subfamily 2D, polypeptide 6; cytochrome P450, subfamily IID, polypeptide 6; Cytochrome P450, subfamily IID4; Cytochrome P450-CMF3; Cytochrome P450-DB4; Debrisoquine 4-hydroxylase; P450 2D-29/2D-35; P450-CMF3; P450-DB4
Gene Aliases: Cyp2d-18; Cyp2d-4; Cyp2d18; Cyp2d22; Cyp2d4; Cyp2d4v1; Cyp2d4v2; Cyp2d6
UniProt ID: (Rat) Q64680
Entrez Gene ID: (Rat) 171522