This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: EKLHEEIDRV IGPSRIPAIK DRQEMPYMDA VVHEIQRFIT LVPSNLPHEA TRDTIFRGYL IPKGTVVVPT LDSVLYDNQE FPDPEKFKPE HFLNENGKFK YSDYFKPFST GKRVCAG
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 4-nitrophenol 2-hydroxylase; CP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-ALC; Cytochrome P450-J; Cytochrome P450RLM6; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-J; P450RLM6; xenobiotic monooxygenase
Gene Aliases: CPE1; CYP2E; Cyp2e-1; CYP2E1; P450-J; P450C2E