This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants.
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Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; Cytochrome P450 39A1; cytochrome P450, family 39, subfamily A, polypeptide 1; cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Oxysterol 7-alpha-hydroxylase
Gene Aliases: CYP39A1
UniProt ID: (Human) Q9NYL5
Entrez Gene ID: (Human) 51302
Molecular Function: oxygenase